The Mixer-Lewis House was constructed from 1900 to 1901 by Knowlton Mixer. Mixer was the co-owner of the Buffalo Lumber Exchange, a prominent lumber company in the area.The home was designed by Mixer’s wife, Jessie May Anthony Mixer (born 1869). Although Jessie was daughter of a prominent businessman and Freemason, she had no formal education in design.

The exterior and interior design details display high levels of craftsmanship and reflect Jessie’s devotion to the English Arts and Crafts movement. Jessie was one of the organizers of a conference on the Arts and Crafts movement in Buffalo in April 1900, and was related to the women’s suffrage advocate Susan B. Anthony.

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